An Overview of Lamictal and Weight Gain Several side effects are possible with Lamictal ® (lamotrigine).Weight gain does appear to be one of them, although it is not among the most commonly reported Lamictal side effects.This data comes from clinical trials where the drug was extensively studied and side effects were documented. U.S. Food & Drug Administration. The patients received either: lamotrigine, lithium, or a placebo for the 18-month duration. It was concluded that lamotrigine may significantly decrease BMI and reduce body weight among individuals with obesity. Average weight changes as a result of lamotrigine administration ranged from -0.38 kg to +1 kg – for an overall average of +0.68 lbs. Pharmacology, adverse reactions, warnings and side effects. Find reviews for Lamotrigine from other patients. reviewed data from 8 placebo-controlled clinical trials (comprised of 1800 participants) and 4 unpublished studies in which lamotrigine was administered to treat bipolar disorder. Talk to your doctor about your concerns in order to determine if Lamictal is right for you. Research suggests that Lamictal modifies neurochemistry by: inhibiting voltage-gated sodium channels, blocking various calcium channels (L-type; N-type; P-type), antagonizing sigma and 5-HT3 receptors, upregulating GABA signaling, and suppressing the release of glutamate and aspartate. Everyone participating in the study had a body mass index (BMI) of between 30 and 40, which placed them in the obese to the severely obese range. How Doctors Choose Between an Atypical and Typical Antipsychotic. (1 kg), and the highest average weight gain in a single trial was 0.68 lbs. To help others fully understand the details associated with your Lamictal use, mention things like: how long you’ve used Lamictal; your Lamictal dosage; whether you use other substances with Lamictal; and whether you are currently underweight, overweight, or obese. lamotrigine). This is very rare, and can even cause weight gain as well. Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. caused weight gain (it did get me off the alprazolam though! (0.7 kg) with placebo. This site uses Akismet to reduce spam. It was further stated that 12.1% of lamotrigine recipients exhibited clinically significant weight loss as a result of treatment. J Clin Psychiatry. appetite change; faster metabolism; increased energy; etc.). Lamictal (lamotrigine) Tablets, Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder, Weight considerations in psychotropic drug prescribing and switching, A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. Always feeling tired? The effect of Lamictal on weight has been studied quite a bit and various clinical trials have found a minimal impact gain. Results indicated that lamotrigine (i.e. Those taking the placebo, meanwhile, lost around seven pounds, so while those taking Lamictal lost more weight, they didn't lose all that much more.. Guerdjikova AI, McElroy SL, Welge JA, Nelson E, Keck PE, Hudson JI. It is also used off-label as an adjunct in treating clinical depression. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. Block, MD, Verywell Mind uses cookies to provide you with a great user experience and for our. Does My Friend or Loved One Have an Eating Disorder? If you experience substantial weight change from Lamictal , share this reaction with a medical doctor. ... black or tarry stool, blood in the stool or urine, rapid weight gain, feeling short of breath or having trouble breathing, irregular heart rhythm or chest pain, dark urine or decreased/stopped urination. In clinical trials, less than 5 percent of those taking Lamictal gained weight. Paul Reynolds. I feel hungry but my stomach is doing some nauseous, crampy thing. The findings in lamictal and vyvanse weight loss this group, increasing the risk for the analysis. – and obese users appear to lose more weight than non-obese users. It was noted that lamotrigine was well-tolerated and unlikely to cause adverse reactions. Lamotrigine (Lamictal® and ... decreased appetite or weight loss; loss of energy or extreme tiredness; slowed movements or agitated behaviour; feelings of worthlessness, guilt or hopelessness; impaired concentration or decision-making skills; thoughts or attempts of suicide ... Lamotrigine may be particularly helpful for patients who have more than four mood episodes per year (this is called rapid … Merideth noted that, unlike most mood stabilizers, lamotrigine isn’t associated with weight gain. Although lamotrigine (~236 mg/day) and placebo were of similar efficacy in decreasing the weekly number of binge eating episodes and binge days, lamotrigine recipients lost more weight (-1.17 kg) compared to placebo recipients (-0.15 kg). Next post: Lamictal Side Effects & Adverse Reactions, Previous post: Lithium & Weight Gain: How Much? doi:10.4088/jcp.v67n0212. Symptoms of Lamictal overdose can include rapid, uncontrollable eye movements, clumsiness and lack of coordination affecting your balance, impaired or loss of consciousness, fits or coma. That said, it is important to keep in mind that the cause(s) of one person’s weight change on Lamictal might differ from the cause(s) of another’s. Zarzar, Graham, Roberts, et al. (What You Should Know), Lamictal Side Effects & Adverse Reactions, Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). The body weights, BMIs, body fat percentages, serum lipids, and glycosylated hemoglobin levels of participants were recorded at baseline – and compared to measures following week 26. Selected from data included with permission and copyrighted by First Databank, Inc. Usually, an unrecognized cancer will have other symptoms or abnormalities of laboratory tests, in addition to unexplained weight loss. 2013 Jul;84(7):796-9. Nevertheless, evidence is based upon average responses to the medication – and does not account for individual variability in reactions. Others affect your energy level. Save to favs. The risk of nonserious rash may be increased when the r… Pickrell, Lacey, Thomas, et al. People with type 2 diabetes are often encouraged to lose weight, as this can help return their blood sugar to normal levels. 2009;24(3):150–158. A. over a 4-month span. Certain mood stabilizers commonly used in bipolar disorder—specifically, lithium and Depakote (valproate)—carry a high risk of weight gain., In addition, the atypical antipsychotic medications Clozaril (clozapine) and Zyprexa (olanzapine) tend to cause significant weight gain in people taking them. That said, if you are concerned about body weight change while using Lamictal – or have already experienced weight change, below are some weight management strategies to consider implementing. Data for the retrospective analysis was derived from multiple double-blind, placebo-controlled, 18-month trials testing lamotrigine and lithium for the management of bipolar disorder. A. 2004: Safety and tolerability of lamotrigine for bipolar disorder. Therefore, if you're already overweight, you and your psychiatrist may want to consider the possibility of additional weight gain in determining your medication regimen for your bipolar disorder. Did you track calories and physical activity throughout Lamictal treatment to verify that the weight change you experienced wasn’t simply due to altered energy intake or expenditure? Non-obese patients exhibited: weight loss of 1.1 lbs. Get Lamictal Coupon Card by print, email or text and save up to 75% off Lamictal at the pharmacy. Does Taking Lithium for Bipolar Disorder Cause Weight Gain? Lamotrigine is a member of the sodium channel blocking class of antiepileptic medications, yet it is enigmatic in that its exact method of action is not known. This should be reassuring to people with bipolar disorder since so many medications used to treat the condition can cause weight gain. Often, a combination of things results in a general decline in your health and a related weight loss. (1.2 kg) over a 52-week span. 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